在早产和眼睛几何之间关系的性别特异性差异
Achim Fieß1, Alica Hartmann1, Eva Mildenberger2
1Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Investigative ophthalmology & visual science
|June 14, 2024
概括
较低的妊娠年龄 (GA) 与成年人中较厚的中央骨厚度有关,在男性中影响更为明显. 这种性别相关性表明发育差异影响成人视力和潜在的疾病风险.
科学领域:
- 眼科医生 眼科 眼科
- 发展生物学 发展生物学
- 人类遗传学 人类遗传学
背景情况:
- 妊娠年龄 (GA) 和出生体重 (BW) 是婴儿发育的关键决定因素.
- 眼睛结构在妊娠期间经历了显著的发展,影响了长期的视力健康.
- 基于性别的生物差异可能会影响发育轨迹和健康结果.
研究的目的:
- 调查成年人怀孕年龄 (GA) 和出生体重 (BW) 百分点与眼睛几何学之间的性别特异关系.
- 为了确定性别是否会改变GA/BW百分位数和眼睛参数之间的关联.
主要方法:
- 对438名成年人 (年龄在18-52岁之间) 进行前性眼科检查,这些人出生于早产或到期.
- 单变量和多变量线性回归分析评估了GA/BW百分位数和眼睛指标之间的关联.
- 关键的眼部测量包括中角膜厚度,角膜半径,前腔深度,透镜厚度,后部段长度和中骨厚度.
- 分析了性别特异性差异和性别对效果的修改.
主要成果:
- 在女性 (B = -2.99) 和男性 (B = -4.27) 中,在更高的GA和中央骨厚度之间发现了负相关性.
- 具有效果修改的多变量分析表明,较低的GA与更厚的中央叶厚度有关.
- 显著的性别-GA相互作用 (B = 1.29,P = 0.04) 表明GA对男性中枢骨厚度的影响更为明显.
结论:
- 下部GA和较厚的中央叶厚度之间存在性别特异的相关性,突出了眼睛发育途径的分歧.
- 在早产的个体中,较厚的中央骨厚度可能会影响成年人视力敏度,特别是在男性中,并导致与年龄相关的疾病.
- 性别没有改变GA或BW百分位与其他评估的眼睛几何参数的关联.
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