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无细胞DNA动力学对肌肉损伤运动的反应:一项跳研究

Ema Juškevičiūtė^1,2, Elmo Neuberger², Nerijus Eimantas¹

¹Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.

Experimental physiology

|June 14, 2024

概括

循环无细胞DNA (cfDNA) 在炼后升高,与疲劳等主要肌肉损伤标志物比疼痛等次要标志物更有联系. 这表明cfDNA是急性肌肉功能丧失的敏感指标.

科学领域:

运动生理学运动生理学
生物标志物生物标志物
肌肉损伤研究肌肉损伤研究

背景情况:

身体炼显著提升循环的无细胞DNA (cfDNA).
需要进一步阐明cfDNA与肌肉损伤标记物的动力学和关系.
了解cfDNA的作用可以提高对运动诱导的肌肉损伤的评估.

研究的目的:

在运动后96小时内跟踪cfDNA和肌肉损伤标记.
检查cfDNA与主要 (如疲劳,MVC) 和次要 (如CK,DOMS) 肌肉损伤指标之间的相关性.
为了确定cfDNA是否是急性肌肉功能丧失的更敏感的标记物.

主要方法:

14名健康的年轻男性进行了50次间歇性跳跃.
测量包括cfDNA,肌酸激酶,最大自愿同度收缩 (MVIC),低频疲劳和延迟发作的肌肉疼痛 (DOMS).
评估是在运动前进行的,并在运动后多个时间点进行,直到运动后96小时.

主要成果:

血cfDNA水平从运动后立即增加到72小时,显著增加.
运动后cfDNA升高与低频疲劳 (r = -0.52) 和DOMS (r = 0.32) 的增加有很强的相关性.
cfDNA变化与初级肌肉损伤变量比二次变量更有联系.

结论:

在应对严重的运动诱导肌肉损伤时,cfDNA水平会动态变化.
与二次炎症或肌肉纤维损伤标志物相比,cfDNA似乎是急性肌肉功能丧失的更敏感的生物标志物.
这项研究强调了cfDNA作为运动诱导肌肉损伤的敏感指标的潜力.

关键词:

血液标记物血液标记物没有细胞的DNA.这是古怪的运动.肌肉损伤肌肉损伤肌肉损伤

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