青少年的NREM慢波活动与ADHD水平有不同的关联,并通过药理治疗正常化
Vivien Reicher1, Orsolya Szalárdy2, Róbert Bódizs2
1Clinical and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary.
The international journal of neuropsychopharmacology
|June 14, 2024
概括
患有ADHD风险的未服用过药物的青少年表现出更大的睡眠慢波活动,这表明皮质成熟延迟. 治疗ADHD的药物似乎能使风险青少年的睡眠模式正常化.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 睡眠医学 睡眠医学
背景情况:
- 据推测,注意力缺陷/多动障碍 (ADHD) 是由于皮质成熟延迟引起的.
- 在非快速眼球运动 (NREM) 睡眠期间的睡眠慢波活动 (SWA) 是皮质成熟的标志物.
- 现有关于ADHD和SWA的研究是矛盾的,对发育轨迹和药物效应的理解有限.
研究的目的:
- 调查ADHD药疗是否影响NREM SWA和ADHD风险之间的关系.
- 为了检查皮质成熟的差异,在药物-naive处于危险的青少年,常用药物处于危险的青少年,和对照.
主要方法:
- 研究了三组青少年:常用药物有患ADHD风险的青少年,未使用药物有患ADHD风险的青少年和对照群.
- 按时间年龄对应的参与者,并对非ADHD药物治疗进行控制.
- 在家庭睡眠期间分析了NREM睡眠脑电图 (EEG) 慢波活动 (SWA).
主要成果:
- 与其他两组相比,在第一次睡眠周期和整个夜晚中,患有ADHD风险的未服用过药物的青少年在NREM SWA中表现出显著更高的NREM SWA.
- 在常用药物治疗的有风险的青少年和没有患ADHD风险的青少年之间,NREM SWA没有发现显著差异.
结论:
- 这些发现支持了在以前没有服用过药物的青少年中患有ADHD风险的非典型皮层成熟的假设.
- 在常用药物治疗的青少年中,ADHD药疗似乎能使NREM SWA正常化,这些青少年有患ADHD的风险.
- 较高的NREM SWA可能代表了患有ADHD风险的青少年发育迟缓的补偿机制.
更多相关视频
13:09Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
Published on: April 1, 2018
10.3K
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
5.7K
相关概念视频
01:30Attention-Deficit/Hyperactivity Disorder
55
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
55
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
168
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
168
01:15REM Sleep Behavior Disorder
180
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
180
01:28Drug Therapy
42
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
42
01:19Management of Insomnia
244
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
244
01:07Narcolepsy
101
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
101