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系统性免疫炎症指数与肺功能,COPD风险和COPD严重程度的关联:基于人口的研究
Ying-da Song1,2, Xiao-Ming Bai1, Jun Ma1
1Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi Province, China.
PloS one
|June 14, 2024
概括
系统性免疫炎症指数 (SII) 与慢性阻塞性肺病 (COPD) 风险增加和肺功能降低有关. 较高的SII水平与较大的COPD严重程度相关,特别是在阻塞性肺部疾病全球倡议第一和第三阶段.
科学领域:
- 肺部医学 肺部医学
- 炎症生物标志物 炎症生物标志物
- 公共卫生 公共卫生
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个主要的全球健康问题.
- 系统性免疫炎症指数 (SII) 是一种反映系统性炎症的新型生物标志物.
- SII和COPD,肺功能和严重程度之间的关联仍然不清楚.
研究的目的:
- 调查SII水平与COPD之间的复杂关联.
- 检查SII和肺功能参数之间的关系.
- 评估美国成年人SII和COPD严重程度之间的相关性.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2005-2018) 的横截面研究.
- 包括18349名参与者;SII是根据血小板,中性粒细胞和淋巴细胞计数计算的.
- 使用后勤回归,子组分析,受限立方线 (RCS) 和倾向得分匹配 (PSM).
主要成果:
- 在增加的Log-SII水平和COPD风险之间发现了积极的关联 (OR 1.39;95% CI 1.16-1.68).
- 观察到SII和1秒内强制呼气量 (FEV1) /强制生命能力 (FVC) %之间的负相关性.
- 在FEV1和SII之间发现了反转的U形关系;高的SII与GOLD 1和GOLD 3的COPD严重程度有关.
结论:
- 逻辑-SII水平与COPD风险有显著的相关性.
- SII显示与肺功能受损的关系.
- 升高的SII表明COPD严重程度增加.
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