无幻影校准CT扫描用于部骨折风险预测:与基于幻影的校准进行比较
Julia A Szyszko1,2, Alessandra Aldieri1,3, Antonino A La Mattina1,2
1Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
PloS one
|June 14, 2024
概括
使用患者组织的无幽灵校准准确地从定量CT扫描中校准有限元模型. 当基于幻象的校准不可行时,这种方法提供了一个可行的替代方案,确保可靠的材料属性映射.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 计算力学 计算力学 计算力学
背景情况:
- 来自定量计算断层扫描 (QCT) 的有限元模型 (FEM) 需要从Hounsfield单位 (HU) 进行材料属性映射.
- 校准通常使用具有已知密度的幻影,但这并不总是实用.
- 无幽灵校准,使用受试者组织作为参考,提供了一个替代方案.
研究的目的:
- 为了比较基于幻象和无幻象的QCT衍生的FEM校准方法.
- 评估绝经后妇女无幻体校准的准确性和可靠性.
主要方法:
- 开发了一种无幽灵校准方法,使用空气,脂肪和肌肉组织在定义的兴趣体积内进行校准.
- 从组织峰值确定了参考HU值,并使用线性回归进行患者特定的校准.
- 使用这两种校准方法生成和比较FEM.
主要成果:
- 方法之间的平均相对差异很小:Young的模量为1.99%,拉伸力为1.30%,压力力为1.34%.
- 在表面菌株中观察到优异的相关性 (R2 > 0.99).
- 最大规范化根平均平方相对误差低于4.02%.
结论:
- 没有幻影的校准方法与基于幻影的校准方法有很好的一致性.
- 这种方法是一种可靠的替代方案,当 QCT 衍生的 FEM 无法进行基于幻象的校准时,这种方法是可靠的替代方案.
- 支持在FEM中采用无幽灵校准来准确地绘制材料属性.
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