腰与身高的比例与腹部大动脉化之间的关联:一个横截面研究
1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
Medicine
|June 14, 2024
概括
腰与身高的比 (WtHR) 是中心肥胖的一个关键指标. 这项研究发现,在美国成年人中,WtHR与腹腔大动脉化 (AAC) 有负面关联,这表明WtHR可能有助于预测心血管风险.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 腰与身高的比率 (WtHR) 是中央肥胖的一个有效的生物标志物.
- 中心肥胖是心血管疾病的重要危险因素.
- 腹腔大动脉化 (AAC) 是动脉样硬化和心血管风险的标志物.
研究的目的:
- 在美国成年人中调查WtHR和AAC之间的关联.
- 确定WtHR是否可以作为严重AAC的预测因素.
- 在不同的人口分组中探索这种关联的潜在变化.
主要方法:
- 利用了2013-2014年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归,灵敏度分析和光滑曲线拟合.
- 进行子组分析和相互作用测试,以评估跨种群的一致性.
主要成果:
- 在3079名40岁以上的参与者中观察到WtHR和AAC之间的负相关性.
- 每增加1个单位的WtHR与严重AAC概率减少2%相关 (OR=0.02).
- 与最低四分位数 (OR=0.61) 相比,WtHR四分位数最高的个体患重型AAC的可能性降低了39%.
- 在WtHR和AAC得分之间发现了一个反转的U形关联,折叠点为0.56.
- 在糖尿病小组中,负面关联更为明显.
结论:
- 在美国成年人中,WtHR与AAC负面相关.
- 较高的WtHR可能与严重腹腔大动脉化的可能性降低有关.
- 这些发现表明WtHR在评估心血管疾病风险,特别是糖尿病患者中的有用性.
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