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在患有食道癌的患者中,术前实验室数据指标的预后价值:一项观察性研究
Hui Ma1,2, Yangchen Liu2, Hongxun Ye2
1Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Su Zhou, P.R. China.
Medicine
|June 14, 2024
概括
系统性免疫炎症指数 (SII) 和预后营养指数 (PNI) 预测食道癌患者的整体存活率. 结合SII和PNI可以提高这些患者的预测准确度.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症预后 癌症预后
背景情况:
- 手术前的实验室标志物会影响瘤预后.
- 在食道癌中SII和PNI的综合预后影响尚不清楚.
研究的目的:
- 在T3N0M0食道癌患者中调查SII,PNI和整体生存 (OS) 之间的关联.
- 评估SII和PNI对OS的综合预测值.
主要方法:
- 对246名T3N0M0食道癌患者 (2010-2022) 的回顾性分析.
- 卡普兰-梅尔分析和多变量考克斯回归用于OS预测因子 (NLR,PLR,LMR,SII,PNI).
- 接收机运行特征 (ROC) 曲线分析用于SII和PNI的联合预测值.
主要成果:
- 单变量分析确定了分化,血管参与,术后治疗,NLR,SII,PLR,LMR和PNI作为OS预测因素.
- 多变量分析证实了分化,SII,PNI和术后治疗作为OS的独立预后因素.
- SII和PNI的组合显示了OS的更高的预测值.
结论:
- NLR,SII,PLR,LMR和PNI是T3N0M0食道癌中OS的独立预测因素.
- 结合SII和PNI显著提高了这些患者预测OS的准确性.
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