重复结到非常低的温度不会影响从EpiPen®和Jext®上腺素自注射器中排出的量
Felix N R Wood1,2, Rosemary Hartley2, Rebecca Boys2
1Academic Department of Military Emergency Medicine, Royal Centre for Defence, Medicine, Birmingham, UK.
International journal of circumpolar health
|June 14, 2024
概括
包括EpiPen®和Jext®在内的上腺素自动注射器在多次极端冷解周期到-80°C后没有显著的功能损失. 这表明这些设备在极地环境中对医疗使用可能仍然有效.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 环境健康 环境健康
背景情况:
- 在冷到-25°C后,EpiPen®自动注射器还能正常工作.
- 在冷后,其他上腺素自动注射器的性能数据有限.
- 极地地区的极寒暴露可能会影响自喷器的功能.
研究的目的:
- 为了评估EpiPen®和Jext®上腺素自动注射器在极端结解周期后的性能.
- 描述多个冷解周期在-80°C对自动注射器功能的影响.
- 提供有关极地医学人员使用自喷器的相关数据.
主要方法:
- 实验室对12种EpiPen®和12种Jext®器件进行了测试.
- 暴露于0,1,5或15个冷解周期,每个周期都需要冷到-80°C,然后恢复到室温.
- 测量暴露后从每个装置喷射出来的液体质量.
主要成果:
- 在对照组和冷解暴露组之间排出的液体质量没有显著差异.
- 无论是EpiPen®还是Jext®自动注射器,在低至80°C的15个循环后,都保持了一致的液体排放.
- 初步发现表明,它们对极端寒冷的暴露有弹性.
结论:
- 多次冷解周期到-80°C不太可能显著影响从EpiPen®和Jext®自喷器中排出的上腺素溶液的体积.
- 这些发现支持这些设备在极寒环境中使用的潜在可靠性.
- 需要进一步的研究来证实上腺素自注射器在极端温度暴露后的安全性和有效性.
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