具有针对巨细胞的抗瘤发生潜力的天然产品
Hao Liu1, Manru Huang1, Dandan Xin1
1State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China.
概括
自然产品调节巨细胞功能,对抗癌症的发展. 这篇评论强调了它们在瘤预防方面的潜力,通过准炎症和瘤微环境.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 炎症是癌症发展的关键风险因素.
- 巨细胞具有可塑性,在瘤发生过程中起着复杂的作用.
- 自然产品为癌症药物发现和优化提供了一个有希望的途径.
研究的目的:
- 综合审查巨细胞在癌症中的作用.
- 探索自然产品如何通过调节巨细胞功能来影响瘤发生.
主要方法:
- 在主要数据库 (PubMed,科学网等) 中进行了PRISMA指导的文献搜索. 在过去的二十年里.
- 包括与巨细胞,瘤发生,天然产品和传统中医相关的搜索术语.
- 不包括非英语/中文文章,不提供全文和重复文本.
主要成果:
- 巨细胞通过炎症,血管新生和侵袭通过调节新陈代谢,非编码RNA和信号来影响瘤发生.
- 自然产品 (例如,维捷辛,埃莫丁) 和草药调节巨细胞的功能,以减少癌症.
- 干预措施的重点是减少炎症和改变瘤微环境.
结论:
- 在瘤发生过程中对巨细胞的机械理解为研究提供了洞察力.
- 已识别的天然产品是未来癌症药物开发的有希望的候选者.
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