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Updated: Jun 23, 2025

Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays
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奥尔金-A,一个TPX2-奥罗拉A小分子抑制剂破坏了阿利塞尔提布诱导的多重合体性在攻击性扩散大B细胞淋巴瘤中

Patrick J Conway1, Bárbara De La Peña Avalos2, Jonathan Dao3

  • 1Department of Molecular Immunology & Microbiology, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, USA; Department of Biomedical Sciences, Keiser University, 2600 N Military Trl, West Palm Beach, Florida, USA.

Neoplasia (New York, N.Y.)
|June 14, 2024
PubMed
概括

一种癌症药物阿利塞尔蒂布 (Alisertib) 可以导致多体性,一种药物耐药性的形式. 将其与Aurkin A结合起来会破坏这种多体化,增加扩散型大B细胞淋巴瘤中的癌细胞死亡.

关键词:
艾利塞尔蒂布 (Alisertib) 是一个形积分症 (Aneuploidy) 是一种无形积分症.细胞循环的细胞周期染色体的不稳定性多重积分症是一种多重积分症.

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