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Updated: Jun 23, 2025

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外源性黑激素给药以减轻热应激的潜力诱导的病理生理学
Guanghu Zhou1, Jingjing Zhang1, Shuang Liu1
1College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Journal of thermal biology
|June 14, 2024
概括
黑素 (MT) 通过改善抗氧化和抗炎反应来保护免受热应激. 这项研究发现,在受热压力的中,MT逆转了对体重,体温和器官功能的负面影响.
科学领域:
- 动物科学动物科学
- 身体生理学 身体生理学
- 生物化学 生化学
背景情况:
- 热应激对家禽生产产生负面影响,导致生理和生化乱.
- 黑色素 (MT) 是一种具有已知的抗氧化和抗炎性能的激素.
研究的目的:
- 为了研究黑色素对的热引起的病理生理损伤的保护作用.
- 为了确定最佳的黑激素剂量,以减轻热应激效应.
主要方法:
- 在21天的时间里,热应激接受了不同剂量的黑激素治疗.
- 评估了血清抗氧化酶,生物化学指数,炎症性细胞因子,热应激标志物和心肺功能.
- 进行了心脏和肺组织的组织学检查.
主要成果:
- 黑色素逆转了由热应激引起的体重减轻和体温升高.
- MT治疗减少了促炎性细胞因子 (IL-1β,IL-6,TNF-α) 和热冲击蛋白70.
- MT增加了总蛋白质,专蛋白和全球蛋白水平,并增加了抗氧化酶活性 (SOD,GPx,CAT).
- 心肺功能指数有所改善,心脏缩和肺堵塞在MT治疗下减少.
- 中等剂量的黑激素 (1 mg/kg/d) 显示出最显著的保护作用.
结论:
- 热应激会在中引起显著的病理生理损伤.
- 外源性黑激素有效地减轻了的热应激诱导的不良影响.
- 一剂量1毫克/千克/天的黑激素提供最佳的保护,防止热应激在家禽.
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