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Updated: Jun 23, 2025

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微生物群决定T细胞克隆选择,在干细胞移植后增强移植对宿主疾病

Albert C Yeh1, Motoko Koyama2, Olivia G Waltner2

  • 1Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.

Immunity
|June 14, 2024
PubMed
概括

移植与宿主疾病 (GVHD) 可能是由微生物群特定的T细胞驱动的,而不仅仅是遗传差异. 这些T细胞向微生物抗原,增加GVHD的严重程度,而不依赖于捐赠者-接受者遗传.

关键词:
CD4 (((+) T 细胞细胞在GVHD中,GVHD是指GVHD在T细胞谱系中,接种与宿主病的疾病.他的兼容性与不兼容性.微生物组是一个微生物组.微生物群 T 细胞干细胞移植是干细胞移植.

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