生物工程人类结肠有机体,其细胞复杂性和功能类似于体内生物
Olga Mitrofanova1, Mikhail Nikolaev1, Quan Xu1
1Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel 4052, Switzerland.
Cell stem cell
|June 14, 2024
概括
研究人员开发了"迷你结肠",先进的人类器官模型,更好地模仿肠道. 这些模型显示了改善的组织寿命和细胞多样性,为研究肠道生理和疾病提供了更准确的体外系统.
科学领域:
- 生物医学工程 生物医学工程
- 胃肠病学 胃肠病学
- 组织工程是组织工程.
背景情况:
- 器官和芯片上的器官是人类肠道生理学的有价值的体外模型.
- 目前的模型往往缺乏体内肠道粘膜的复杂性和成熟度.
- 需要先进的模型来更紧密地复制本地组织特征.
研究的目的:
- 开发一种先进的人类器官模型,克服现有系统的局限性.
- 为了创建一个与人肠道组织密切相似的模型.
- 为药物安全性评估建立一个可靠的临床前平台.
主要方法:
- 整合了有机体和器官在芯片上的技术,以创建"迷你结肠".
- 不对称生长因子刺激以增强组织寿命和细胞多样性.
- 单细胞RNA测序以分析细胞类型和成熟.
主要成果:
- 迷你结肠表现出增强的组织寿命和体内类似的细胞类型多样性和模式.
- 观察到大量的产生粘液的玻璃杯细胞和成熟的功能性结肠细胞.
- 该方法被扩展到小肠微组织,并添加了额外的微环境成分.
结论:
- 生物工程迷你结肠为研究人类肠道生理学和病理学提供了一个精确的平台.
- 这些先进的有机体作为药物安全性评估的可靠临床前模型.
- 开发的技术在人体胃肠道体外建模方面取得了进展.
相关概念视频
What are Cells?
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.Basic Characteristics of CellsA living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.Furthermore, a living cell possesses genetic information...
Tissues
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
What are Cells?
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Structural Organization of the Human Body: An Overview
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
Cell Diversity
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...
Multicellular organisms...
Tissues
Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...


