基托桑纳米颗粒与咖叶精油结合:物理化学特征和体外释放特性
R Nur Fatin Nazurah1, M A Noranizan1, M A R Nor-Khaizura2
1Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
International journal of biological macromolecules
|June 14, 2024
概括
咖叶精油 (CLEO) 通过纳米封装和纳米沉被封装成纳米结构. 这些方法增强了油的抗氧化和抗微生物特性,提供了稳定的输送系统.
科学领域:
- * 纳米技术的使用
- * 制药科学 制药科学
- * * 自然产品化学 自然产品化学
背景情况:
- * 精油,包括咖叶精油 (CLEO),具有宝贵的抗氧化剂,抗微生物和驱虫性能.
- * 精油中生物活性化合物的挥发性限制了它们的应用和稳定性.
- * 开发有效的输送系统对于保护和提高天然化合物的疗效至关重要.
研究的目的:
- *通过制造纳米尺寸颗粒来改善咖叶精油 (CLEO) 的生物特性.
- * 为了比较纳米封装和纳米沉方法,用于生产带有CLEO载荷的酸盐纳米结构.
- * 评估由此产生的纳米结构的稳定性,抗氧化和抗菌活性.
主要方法:
- *使用纳米封装和纳米沉技术合成纳米结构.
- *使用传输电子显微镜 (TEM) 和富里埃转换红外光谱 (FTIR) 进行纳米结构的表征.
- *对稳定性,抗氧化活性 (DPPH测定),抗菌性质和体外释放动力学等zeta潜力的评估.
主要成果:
- * 纳米封装和纳米沉都成功地产生了封装CLEO.的稳定酸盐纳米结构 (zeta潜力>+30 mV).
- *与纳米球相比,装有CLEO的纳米囊显示出与格拉姆阳性细菌的优越抗菌活性.
- * 装有CLEO的纳米球比纳米囊具有更高的抗氧化活性 (90.44% DPPH激素清除)
- * 增加基托桑度可以增强抗氧化和抗菌活性.
- *体外释放研究显示释放机制有两个阶段:在12小时内迅速释放,随后持续释放.
- * 两种方法都实现了高封装效率 (>60%).
结论:
- *纳米封装和纳米沉是生产稳定的纳米结构的可靠技术,可以保护CLEO的生物活性成分.
- *开发的纳米结构显著增强了CLEO的抗氧化和抗菌特性.
- *这些发现表明,纳米封装CLEO在需要天然活性成分的各种领域的潜在应用.
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