在健康的老年人中,个人暴露于空气中的有机污染物和肺功能变化
Xiaojie Guo1, Huimin Ren2, Peijie Sun2
1China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; School of Public Health, Southern Medical University, Guangzhou, Guangdong 510515, China.
空气中的污染物,如二二-1-甲基乙烯,会损害老年人的肺功能 (FVC). 甘油脂可能会提供保护,像HMGB1信号传递这样的途径与机制有关.
科学领域:
- 环境健康 环境健康
- 肺部病理学 肺部病理学
- 毒理学 毒理学 毒理学
- 老年学是一门学科.
背景情况:
- 关于空气中的有机污染物对老年人的肺功能影响的流行病学数据有限.
- 关联污染物暴露与老年人呼吸系统衰退的潜在生物机制尚不清楚.
研究的目的:
- 调查个人暴露在空气中的有机污染物对健康老年人肺功能的影响.
- 通过使用多omics数据,阐明这些污染物影响肺部健康的生物机制.
主要方法:
- 在中国济南进行了长度小组研究,对76名健康的老年人进行了5个月的研究.
- 用可穿戴的被动采样器对各种空气中的有机污染物进行个人暴露评估.
- 肺功能测试和多组 (血液和尿液) 分析,加上相互作用分析,因果推断测试 (CIT) 和整合性途径分析 (IPA).
主要成果:
- 2--1-甲基乙烯 (BCIE) 暴露与强迫生命能力 (FVC) 的降低有显著关联.
- 甘油脂被确定为BCIE对FVC的不良影响的潜在缓解因素.
- 包括HMGB1信号传导,PI3K/AKT通路,上皮层介质细胞过渡和NAD生物合成在内的31种正规通路被认为是潜在的机制.
结论:
- 特定的空气中的有机污染物,如BCIE,可以对老年人的肺功能产生负面影响.
- 多组和通路分析揭示了潜在的生物机制,包括特定的信号通路和代谢过程.
- 研究结果表明,需要有针对性的策略,以减轻老龄化人口中空气中的污染物造成的呼吸风险.
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