使用定制的pH驱动方法在素中封装三种不同类型的多醇:制备和表征
Xiao Wang1, Chao Chen2, Yulong Bao1
1School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Food research international (Ottawa, Ont.)
|June 14, 2024
概括
这项研究开发了一种新的pH驱动的封装方法,使用素纳米颗粒来改善酸和白醇等化合物的可溶性和稳定性. 这种技术提高了它们在食品和生物医学应用中的抗氧化功效.
科学领域:
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
- 食品科学 食品科学 食品科学
背景情况:
- 化合物具有有价值的生物特性,但具有较差的水溶性和较低的口服生物利用性.
- 封装系统提供了一个有希望的策略,通过提高化合物的稳定性和可溶性来克服这些局限性.
研究的目的:
- 为化合物开发一种新的,定制的pH驱动的封装方法.
- 为了确定封装ferulic acid,resveratrol和rhein的最佳pH条件.
- 为了提高这些多的可溶性,稳定性和抗氧化疗效.
主要方法:
- 在各种pH值下分析ferulic acid,resveratrol和rhein的可溶性,稳定性,LogD和LogS曲线.
- 使用已确定的最佳脱点将多醇封装成素纳米颗粒.
- 使用FTIR光谱,光谱和分子对接的纳米粒子的表征.
主要成果:
- 确定了最佳的脱点:酸 (pH 9),复星 (pH 11) 和莱因 (pH 10).
- 使用稳定的素纳米粒子实现了高封装效率 (95.86%,94.62%,94.18%).
- 光谱和对接研究证实了通过和疏水性相互作用的聚烯封装.
- 素纳米颗粒显著提高了封装的多的水溶性和抗氧化活性.
结论:
- 一种定制的pH驱动封装技术有效地解决了多的不稳定性和降解问题.
- 这种方法增强了多的溶解性,稳定性和抗氧化疗效,为它们在食品和生物医学领域的应用铺平了道路.
- 开发的素纳米颗粒为改善自然化合物的生物可用性和应用提供了一个有前途的输送系统.
相关概念视频
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01:19Mixtures of Acids
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