相关实验视频

Updated: Jun 23, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

准TGFβ受体介导的牛和扭曲:WSG,Ganoderma lucidum中的多糖和基于它的可溶性微针贴片可以抑制黑色素瘤细胞

Hung-Chih Lo¹, Tzu-En Lin², Che-Yu Lin³

¹Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Carbohydrate polymers

|June 14, 2024

概括

光衍生水溶性葡萄糖 (WSG) 有效抑制黑色素瘤细胞的生长和转移. 一种新的微针贴片 (MN-WSG) 提供了这种强大的抗黑色素瘤化合物的增强输送.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

皮肤黑色素瘤是一种具有有限向治疗的侵袭性皮肤癌.
(Ganoderma lucidum) 是一种被用作补充癌症治疗的.
来自Ganoderma lucidum的水溶性葡萄糖 (WSG) 需要对抗黑色素瘤作用进行调查.

研究的目的:

为了研究WSG的抗黑色素瘤作用.
探索WSG对黑色素瘤细胞活力,移动性和上皮细胞转移到介质细胞 (EMT) 的影响.
开发和评估一种新的微针贴片 (MN-WSG) 用于WSG输送.

主要方法:

在体外研究评估了黑色素瘤细胞活力,移动性和EMT标志物.
西方涂抹分析了EMT因子和信号通路 (TGFβR,FAK,ERK1/2,Smad2) 的蛋白质表达.
在体内研究中使用了B16F10黑色素瘤携带的小鼠;使用PVA和PVP制造微针贴片.

主要成果:

WSG显著抑制了黑色素瘤细胞的活力和移动性.
WSG降低了EMT标记物Snail和Twist的调控,并降低了TGFβR信号传输.
在体内,WSG抑制了瘤的生长,MN-WSG的疗效与单独的WSG相美.

结论:

通过抑制细胞增殖,迁移和EMT,WSG对黑色素瘤具有显著的治疗潜力.
开发的MN-WSG补丁为WSG提供了一个有效和新的交付系统.
WSG和MN-WSG代表了黑色素瘤治疗和药物输送的有希望的途径.

关键词:

这是一种抗癌药物.这种植物叫做Ganoderma lucidum.黑色素瘤是一种黑色素瘤.微针微针的使用方法它是一种多糖化合物.

更多相关视频

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues

Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues

Published on: July 8, 2020

相关概念视频

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...