药物干旱在孕产妇健康:一个持续的困境
Anne Ammerdorffer1, Annie R A McDougall2, Andrew Tuttle3
1Concept Foundation, Geneva, Switzerland.
The Lancet. Global health
|June 14, 2024
概括
对产妇健康药物的审查发现创新有限,发展缓慢. 大多数候选药物都处于早期阶段,这凸显了孕妇市场持续失败的现象.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 孕产妇健康 孕产妇健康
背景情况:
- 孕产妇的健康是一个关键的全球健康问题.
- 对于治疗与怀孕有关的疾病的有效药物,存在着大量未满足的需求.
- 历史上,孕产妇健康治疗药物的开发管道一直是不够的.
研究的目的:
- 创建一个全面的药物数据库,用于活跃发育中的与怀孕有关的疾病.
- 分析前,早产,产后出血,子宫内生长限制和胎儿痛苦的候选药物.
- 确定2000年至2021年间产妇健康医学发展的趋势和挑战.
主要方法:
- 制药候选药物的系统数据库开发.
- 纳入标准侧重于诸如子前期,早产和产后出血等疾病.
- 数据收集从2000年到2021年10月期间进行了积极的发展.
主要成果:
- 确定了444种候选药物用于孕产妇健康状况.
- 大约50%正在积极开发中,其中三分之二是从其他迹象重新使用的.
- 其中不到一半是在临床前研究中,截至2021年10月,只有64人处于晚期 (3期) 发展阶段.
结论:
- 在孕产妇保健药物方面,仍然存在显著的创新不足.
- 由于发育缓慢和选择有限,市场继续失败孕妇.
- 迫切需要采取集体行动,加快投资和开发新的孕产妇健康疗法.
更多相关视频
05:13Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
184
05:04A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
423
相关概念视频
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
267
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
267
Prescription, Nonprescription and Orphan Drugs
719
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
719
Physiological Barriers
3.5K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
3.5K
Drug Delivery: Parenteral Route
492
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
492
Disorder of Water Balance
355
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
355
Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
