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Updated: May 11, 2026

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
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没有证据表明SIV感染的ART正在进行复制

Taina T Immonen1, Christine M Fennessey1, Leslie Lipkey1

  • 1AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.

Nature communications
|June 14, 2024
PubMed
概括

有效的抗逆转录病毒疗法 (ART) 可以阻止HIV-1的复制. 这项对 rhesus 的研究证实了ART期间的病毒演化最小,支持其有效性和NHP模型.

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...