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Updated: Jun 23, 2025

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
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Published on: June 8, 2018

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在CRISPR/Cas9诱导的双链断裂中发现精确修复的动态

Daniela Ben-Tov1, Fabrizio Mafessoni1, Amit Cucuy1

  • 1Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.

Nature communications
|June 14, 2024
PubMed
概括

由于精确的DNA修复,CRISPR/Cas9基因编辑效率受到限制. 这项研究量化了CRISPR/Cas9切割和修复动态,揭示了高保真性修复显著影响突变发生的结果.

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