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美国成年人中氧化平衡得分和慢性病事件之间的关联:基于人口的研究
Yuewei Yin1, Chenming Zhao1, Yalin Niu1
1Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Scientific reports
|June 14, 2024
概括
通过氧化平衡得分 (OBS) 测量较高的抗氧化剂状况,与美国成年人慢性病 (CKD) 的患病率较低有关. 保持良好的OBS可能有助于预防CKD,特别是在那些有轻度至中度风险的人群中.
科学领域:
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
背景情况:
- 氧化平衡评分 (OBS) 通过饮食和生活方式来评估抗氧化剂状况.
- 慢性病 (CKD) 是一个重要的公共卫生问题.
- 了解影响CKD患病率的因素对于预防至关重要.
研究的目的:
- 调查氧化平衡得分 (OBS) 与美国成年人慢性病 (CKD) 患病率之间的关联.
- 探索不同CKD风险层之间的关系.
- 为了确定更高的抗氧化剂状态是否对CKD有保护作用.
主要方法:
- 从NHANES (2007-2018) 中对13373名美国成年人的横截面分析.
- 使用20个饮食和生活方式组件计算OBS.
- 使用白蛋白与肌素比率和eGFR确定CKD;风险分层为轻度,中度和高度.
- 后勤回归和受限制的立方线用于统计分析.
主要成果:
- 在OBS和CKD患病率之间发现了统计学上显著的负相关性.
- 较高的OBS四分位数与慢性脏病的可能性降低有关 (OR 0.70).
- 在整体人群中观察到OBS和CKD几率之间的非线性,反向关联.
结论:
- 升高的OBS可以作为CKD的主要预防策略.
- 在轻度至中度风险组中,OBS对CKD的保护作用似乎更为明显.
- 研究结果强调了抗氧化剂在CKD风险管理和预防中的作用.
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