在没有糖尿病的男性中,empagliflozin对生殖系统的影响
Christophe Kosinski1,2, Georgios E Papadakis3, Olivier Salamin4
1Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. christophe.kosinski@hug.ch.
Scientific reports
|June 14, 2024
概括
用于糖尿病和心力衰竭的-葡萄糖共运输体2 (SGLT2) 抑制剂不会影响男性生殖激素. 在健康男性中,empagliflozin治疗对雄激素或垂体淋巴激素水平没有影响.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- -葡萄糖共运输体2 (SGLT2) 抑制是治疗2型糖尿病,脏疾病和慢性心力衰竭的治疗策略.
- 编码SGLT2,SLC5A2的基因在皮和丸中表达,这表明它可能在淋巴腺功能中发挥作用.
- 以前的研究还没有完全阐明SGLT2抑制对男性生殖激素的影响.
研究的目的:
- 研究SGLT2抑制剂治疗对健康男性的淋巴腺和类固醇激素的影响.
- 为了确定empagliflozin是否会影响没有糖尿病的男性的丸激素产生或其他生殖激素水平.
主要方法:
- 一项双盲,随机,安慰剂控制的研究对26名健康男性进行了后期分析.
- 参与者接受了安慰剂或empagliflozin (每天10毫克) 四周.
- 测量了雄激素,垂体性腺激素和B抑制素的血清水平.
主要成果:
- 一个月的empagliflozin治疗没有导致雄激素,垂体性腺激素激素或抑制B水平的显著变化.
- 无论BMI类别如何,血清中雄激素水平没有明显的变化.
- 抑制SGLT2并没有影响莱迪格细胞的丸激素产生或塞尔托利细胞的抑制B分泌.
结论:
- 用empagliflozin抑制SGLT2似乎不会影响健康男性的淋巴腺功能或激素产生.
- 丸中SGLT2的存在不会转化为其抑制后改变的生殖激素配置文件.
- 在没有糖尿病的男性中,SGLT2抑制剂可以安全地用于他们的生殖激素平衡.
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