ACE2通过修复涉及mTOR通路的肠道屏障来调解腹的托芬缓解
Jinze Li1, Yingli Yan1, Yang Fu1
1State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 受体ACE2和转运体B0AT1促进托的吸收,缓解肠道损伤和腹. 这条通路通过mTOR信号通路修复肠道屏障.
科学领域:
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- ангиотензин转化酶2 (ACE2) 和宽中性氨基酸载体1 (B0AT1) 是参与营养物质运输的肠道受体.
- ACE2/B0AT1在托介导的肠损伤中的作用,特别是在严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的背景下,仍然不清楚.
研究的目的:
- 调查ACE2/B0AT1在通过酸盐运输缓解脂聚糖 (LPS) 诱导的肠损伤和腹中的作用.
- 阐明分子机制,包括拉巴素 (mTOR) 途径的机械性标,这是托的保护作用的基础.
主要方法:
- 用断奶小猪和IPEC-J2细胞作为肠道损伤的模型.
- 使用脂聚糖 (LPS) 诱导腹和炎症.
- 补充了托 (Trp) 的饮食,并分析了ACE2/B0AT1表达,肠道形态和信号通路 (AhR,mTOR).
主要成果:
- 通过ACE2/B0AT1介导的托芬运输缓解了LPS诱导的腹,并促进了肠道屏障的修复.
- 食托补充剂增强了ACE2/B0AT1表达,修复了肠道形态,并减少了LPS治疗小猪的腹.
- ACE2 影响了亚利碳化合物受体 (AhR) 和机械标的拉巴胺素 (mTOR) 途径活性.
结论:
- ACE2和B0AT1在调解托对肠道损伤的保护作用方面发挥着至关重要的作用.
- 托芬可以缓解腹,并通过mTOR途径促进肠道屏障的修复,突显出一种新的治疗策略.
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