基底膜相关基因表达作为口腔癌生存的预测因子
Xu Wang1, Chaoge Liu2,3, HuiFang Wu1
1Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, Laboratory of Clinical Applied Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China.
BMC cancer
|June 14, 2024
概括
底层膜相关基因 (BMGs) 可以预测口腔癌患者的生存率. 一个新的基于BMG的风险评分有效地识别出预后较差的患者,与免疫反应相关,表明治疗潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 底层膜 (BM) 完整性对癌症进展至关重要.
- 特定的BM相关基因 (BMGs) 可能在口腔癌中具有预后价值.
- 了解BMG可以为口腔癌的发展和患者的结果提供见解.
研究的目的:
- 为了研究地下膜相关基因在口腔癌的预后意义.
- 开发和验证基于BMG的风险评分,用于预测口腔癌患者的生存率.
- 探索BMG,免疫透和口腔癌中的免疫检查点之间的关系.
主要方法:
- 关于BM相关基因,口腔癌转录组和临床信息的综合公共数据.
- 识别了差异表达的BMG,并使用考克斯和拉索回归构建了风险得分.
- 在独立队列 (GSE42743) 中验证了风险评分.
- 进行功能丰富,免疫细胞透和免疫检查点分析.
- 在口腔癌组织中通过qRT-PCR和免疫组织化学量化LAMA3表达.
主要成果:
- 确定BMG LAMA3,MMP14和GPC2是显著的预后标志物.
- 开发了一个基于BMG的风险评分,高得分与口腔癌患者的整体存活率较差相关.
- 与风险相关的BMG与免疫功能,免疫细胞透和免疫检查点表达有显著的关联.
- 在口腔癌组织中证实了上调的LAMA3表达.
结论:
- 基于BMG的风险评分是口腔癌的可靠预后指标.
- 鉴定到的BMG和风险评分为临床应用和进一步研究提供了潜力.
- BMG在瘤微环境和口腔癌的免疫调节中发挥作用.
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