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肠道微生物组和心脏代谢并发症在与艾滋病毒感染者生活的人群

Marius Trøseid^1,2,3, Susanne Dam Nielsen^4,5,6, Ivan Vujkovic-Cvijin^7,8,9,10

¹Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. marius.troseid@medisin.uio.no.

|June 14, 2024

概括

艾滋病毒感染者 (PLWH) 的肠道微生物组发生变化,与心血管疾病 (CVD) 风险有关. 虽然还不是生物标志物,但这些肠道变化和代谢产物提供了未来的治疗和精准医学潜力.

科学领域:

微生物组研究的研究.
艾滋病毒/艾滋病研究研究
心血管疾病是什么心血管疾病

背景情况:

抗逆转录病毒疗法 (ART) 可以减少艾滋病毒的进展,但不能消除诸如心血管疾病 (CVD) 等炎症性并发症.
肠道微生物组被认为是艾滋病毒感染者 (PLWH) 的这些并发症的促成因素.
其他因素包括传统风险,共感染,ART毒性和过去的免疫缺陷.

研究的目的:

审查当前关于肠道微生物组在PLWH中并发症中的作用的知识.
专注于心脏代谢并发症,炎症和微生物代谢物.
讨论生物标志物和精准医学的潜力.

主要方法:

关于与艾滋病毒相关的肠道微生物组研究近期进展的文献综述.
对PLWH中的失生症,微生物转移和代谢物的研究分析.
检查与并发症和肠道微生物群相关的循环代谢物.

主要成果:

即使在控制混因子后,PLWH也表现出改变的肠道微生物组.
与艾滋病毒相关的微生物组显示,短链脂肪酸 (SCFA) 生产减少,类似于与心血管疾病相关的个人资料.
具体的代谢物如 propionate, imidazole propionate 和 indole-3-propionic acid 在与并发症相关的情况下进行讨论.

结论:

肠道微生物组概况和代谢物尚未确定为临床生物标志物或治疗点.
需要进一步的研究来将研究结果转化为PLWH的临床实践.
精准医学方法是有前途的,但需要仔细考虑挑战.

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