雷米马佐拉姆与普罗波 (propofol) 麻醉对神经血管外科手术术后痴呆症的影响:随机对照,非劣势性试验的研究方案
Jeayoun Kim1, Seungwon Lee1, Boram Park2
1Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
这项研究将雷米马佐拉姆与神经外科患者麻醉时的普罗波进行比较,以了解它是否会影响术后狂妄 (POD). 结果将指导麻醉选择,以尽量减少POD风险.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 雷米马佐拉姆是一种短效的二,已被批准用于全身麻醉的诱导和维持.
- 它的快速出现和保持 perfusion 压力的能力使它适合用于神经外科手术.
- 然而,类药物可能会增加术后妄 (POD) 的风险,对基于雷米马佐拉姆的麻醉和POD的数据有限.
研究的目的:
- 评估基于雷米马佐拉姆的全静脉麻醉 (TIVA) 对神经外科患者POD发病率的影响.
- 为了比较RemimazolamTIVA与PropofolTIVA在POD开发方面.
- 为选择最佳麻醉剂提供证据,以减少这一人群中POD风险.
主要方法:
- 一个双盲,随机的,非劣势性试验,涉及696名接受选择性神经血管手术的成年患者 (ASA I-III).
- 随机分配的患者在1:1的比例下接受雷米马佐拉姆或基于的TIVA.
- 主要结局:POD发生率在5天内;次要结局包括POD特征,出现激动,意识,血液动力学稳定性和认知功能.
主要成果:
- 这一部分应在试验结果可用后填写.
结论:
- 这项试验将确定雷米马佐拉姆麻醉是否与普罗波相比影响POD发病率.
- 这些发现将为在神经外科中选择麻醉剂的临床实践提供信息,以减轻POD风险.
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