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09:22
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
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肠内血管密度与酸化和TDP-43病理学相关
Josué Llamas Rodríguez1, André J W van der Kouwe1, Jan Oltmer1,2
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
概括
脑内皮层和脑周皮层的血管密度与早期阿尔茨海默病的病理学有关. 特定大脑区域的血管密度较高与临床前阶段的和TDP-43积累增加有关.
科学领域:
- 神经科学是一个神经科学.
- 脑血管生物学 脑血管生物学
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 脑内皮层 (EC) 和脑外皮层 (PC) 对记忆至关重要,在阿尔茨海默病 (AD) 中很容易受到伤害.
- 血管功能障碍越来越多地被认为是AD病变的贡献者,可能与tau和TDP-43.3等蛋白质病变相互作用.
研究的目的:
- 调查EC和PC中大脑血管和神经病理学之间的关系.
- 量化EC和PC特定子领域的血管密度,并将其与早期AD阶段的tau和TDP-43病理相关联.
主要方法:
- 高分辨率 (100μm3) 活体7特斯拉MRI被用于对死后人类大脑组织进行成像.
- 单个血管的手动标记在每例数百个切片中进行.
- 血管密度被量化并与tau和TDP-43病理学的半量化得分空间相关.
主要成果:
- 周内皮层 (PC) 显示出比内内皮层 (EC) 更高的血管化.
- 与前面的区域相比,后面的EC子区域显示出较高的船舶密度.
- 在血管密度和tau和TDP-43病理之间发现了显著的正相关性.
- 在临床前阶段患有严重tau病理的大脑区域的血管密度明显更高.
结论:
- 在AD的临床前阶段,血管密度与EC和PC的tau和TDP-43负担密切相关.
- 特定区域,如周围区域35和后部EC,显示出高的p-tau和血管密度.
- 血管系统和病理学之间的空间关系表明,在早期AD检测中,有预测模型的潜力.
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