微剂量是一个安慰剂吗? 快速回顾低剂量LSD和psilocybin研究的研究成果
Vince Polito1, Paul Liknaitzky2,3
1School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Journal of psychopharmacology (Oxford, England)
|June 15, 2024
概括
有证据表明,迷幻微剂量,包括LSD和 псилоцибин,可能会导致超越安慰剂的真实效应. 然而,需要更多的研究来确定微剂量是否纯粹是一种安慰剂效应.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 临床心理学 临床心理学
背景情况:
- 最近的评论表明,迷幻微剂量效应主要是安慰剂或期望驱动的.
- 科学界需要强有力的证据来验证或反驳这些说法.
研究的目的:
- 进行快速审查,评估心理迷幻微剂效应的安慰剂解释的证据.
- 评估当前研究在区分实际效应与安慰剂反应方面的强度.
主要方法:
- 一个系统的PubMed搜索进行了安慰剂控制的迷幻微剂研究.
- 确定了19项相关研究,并对积极和无效结果进行了分析.
- 偏差风险是使用Cochrane随机试验偏差风险工具进行评估的.
主要成果:
- 经过审查的研究表明,与安慰剂相比,小剂量LSD和 псилоцибин可以改变神经生物学,生理学,主观经验,影响和认知.
- 当前研究的方法限制包括小样本大小,潜在的剂量依赖性和选择偏差.
- 在现有研究中,预期效应的影响似乎很小.
结论:
- 目前的证据不足以得出结论,即迷幻微剂量主要是安慰剂效应.
- 微剂量研究中的方法差距和挑战需要进一步调查.
- 仅仅将微剂量效应归因于安慰剂的说法是过早的,考虑到目前的数据.
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