另类磁场暴露通过代谢重编程抑制瘤生长
Taisuke Akimoto1, Md Rafikul Islam2, Akane Nagasako3
1Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
Cancer science
|June 15, 2024
概括
交替磁场 (AMF) 通过增强氧化酸化和代谢重编程,直接抑制质母细胞瘤的生长. 这种方法选择性地向癌细胞,为脑瘤提供了一种新的治疗策略.
科学领域:
- 生物物理学的生物物理.
- 在瘤学瘤学.
- 代谢工程是代谢工程.
背景情况:
- 超声波和电场等物理力量在临床上使用,但它们的机制往往不清楚.
- 缺乏全面的研究模型,阻碍了对物理力量在医学中的应用的理解.
研究的目的:
- 研究交替磁场 (AMF) 的直接抗癌作用.
- 阐明AMF对癌细胞代谢和增殖的影响的机制细节.
主要方法:
- 暴露人类质母细胞瘤 (GBM) 和正常人类星细胞 (NHA) 细胞在特定频率的AMF.
- 在体内研究,使用小鼠模型与人类GBM异种移植.
- 评估氧化酸化 (OXPHOS),活性氧物种 (ROS),超氧化脱酶 (MnSOD),细胞外酸化率 (ECAR) 和氧气消耗率 (OCR).
主要成果:
- AMF (大约227 kHz) 抑制了GBM细胞的增殖,但没有抑制NHA细胞.
- 在小鼠模型中,AMF治疗显著抑制了瘤生长和延长了生存时间.
- AMF暴露增加了ROS和MnSOD,降低了ECAR,并在GBM细胞中增加了OCR,表明代谢重编程.
结论:
- 通过增强OXPHOS和诱导GBM细胞中的代谢重编程,AMF具有直接的抗癌作用.
- AMF选择性地准癌细胞,这表明利用氧化压力的潜在治疗策略.
- 通过代谢重编程,AMF提供了一种直接的方法来抑制癌细胞的生长.
相关概念视频
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
02:53Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K