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的CRTC1::TRIM11皮肤瘤与转移

Calvin Tseng¹, Erica C Koch Hein^2,3, Stephen M Smith¹

¹Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Journal of cutaneous pathology

|June 15, 2024

概括

本病例报告详细介绍了一种罕见的转移性CRTC1::TRIM11皮肤瘤 (CTCT),表现为. 这些发现表明,CTCT的一个子集可能表现出侵略性行为,突出了对最佳治疗方法进一步研究的需要.

科学领域:

在瘤学瘤学.
皮肤病理学皮肤病理学
基因组医学是基因组医学.

背景情况:

CRTC1:TRIM11皮肤瘤 (CTCT) 是一种罕见的新生体,其分化不确定.
转移在CTCT中并不常见,在报告的病例中,随访数据有限.

研究的目的:

呈现一种转移性CTCT病例与,一种以前未被描述的组织学特征.
为了突出CTCT的一个子集的攻击潜力.
为了解CTCT的临床行为和治疗做出贡献.

主要方法:

组织病理学检查和免疫组织化学 (SOX10,S100,MiTF,NTRK,HMB-45,PRAME).
下一代测序用于识别CRTC1:TRIM11融合.
手术干预 (截肢,哨兵淋巴结活检) 和辅助免疫疗法 (尼沃卢马布).

主要成果:

一名75岁的男性出现了转移性CTCT,呈现出和淋巴血管侵袭.
这种瘤被证实具有CRTC1::TRIM11融合.
尽管接受了治疗,但患者出现了区域性淋巴结复发,并怀疑肺转移.

结论:

这种病例证明了作为CTCT的一个特征,并提供了包括转移在内的侵略性行为的证据.
这些发现强调需要进一步研究CTCT的最佳外科和医疗管理策略.

关键词:

人类CRTC1蛋白质人类CRTC1蛋白质人类TRIM11蛋白质人类皮肤瘤的新生体.

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