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阿迪波斯Kiss1控制了与有氧运动相关的适应性反应,用于脂肪组织能量恒温

Chunyu Liang^1,2,3,4, Xuehan Li^1,2, Ge Song^1,2

¹Department of Sport Biochemistry, School of Sport Science, Beijing Sport University (BSU), Beijing, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|June 15, 2024

概括

脂肪吻1 (kisspeptin) 信号影响能量平衡,特别是在女性身上. 运动诱导的Kiss1在脂肪中影响葡萄糖,脂质代谢和氧气吸收,这表明它在运动适应中发挥了作用.

科学领域:

代谢调节代谢调节代谢调节
内分泌学在内分泌学.
运动生理学运动生理学

背景情况:

基斯佩普丁信号传递对于能量恒温至关重要.
脂肪组织是kisspeptin的关键调节器和受体,运动刺激Kiss1基因表达.
脂肪Kiss1在能量平衡和运动适应中的特定作用尚未完全理解.

研究的目的:

研究脂肪Kiss1在调节能量恒温中的作用.
为了确定长时间炼后由脂肪Kiss1诱导的适应性变化.
阐明脂肪Kiss1对对运动的代谢和生理反应的性别依赖的影响.

主要方法:

使用脂肪特异性的Kiss1淘汰 (Kiss1adipoq-/-) 和Kiss1过度表达 (Kiss1adipoq超过) 的小鼠模型.
评估脂质和葡萄糖平衡,以应对改变的Kiss1水平.
在长时间有氧运动后,分析了内脏白脂肪组织 (gWAT) 和肌肉肌肉中的基因和蛋白质表达.
测量最大的氧气摄入量 (VO2max).

主要成果:

脂肪酸衍生的kisspeptin以性别依赖的方式调节脂质和葡萄糖平衡,女性的效果更大.
Kiss1影响运动后女性gWAT中三碳酸 (TCA) 循环和氧化酸化 (OxPhos) 途径的适应性变化.
在运动后的雌性小鼠中,脂肪Kiss1缺陷降低了单体肌肉PGC-1α蛋白质含量和VO2max.

结论:

脂肪吻1信号在维持系统能量平衡中起着重要作用.
脂肪吻1调解了对长时间运动的适应性反应,特别是在女性身上.
阿迪波斯基斯佩可以作为一种新的阿迪波金,增强器官对代谢基质和运动后氧气的敏感性.

关键词:

脂肪组织的脂肪组织.有氧氧化氧化是有氧的氧化.能量代谢能量代谢运动运动运动.亲吻一个吻一个吻亲吻peptin 的时间

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