在玻璃中毒性和建模揭示了纳米塑料对海洋双动物的影响
Yanfei Zhou1, Xiao-Xia Zhou2, Hao Jiang3
1Institute of Environmental Research at the Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China.
ACS nano
|June 15, 2024
概括
纳米塑料 (NP) 对海洋双生物构成环境风险,导致生长抑制和DNA损伤. 计算模型与体外分析相结合,准确地预测了Ruditapes philippinarum中的这些毒性作用.
科学领域:
- 环境毒理学环境毒理学
- 海洋生物学 海洋生物学
- 生态毒理学 生态毒理学
背景情况:
- 纳米塑料 (NP) 在海洋生态系统中积累,对地生物和食品安全构成风险.
- 评估NP毒性传统上面临着时间和道德限制的挑战.
研究的目的:
- 研究纳米塑料对海洋双鱼Ruditapes philippinarum的毒理影响.
- 评估体外测试和计算建模在预测NP毒性的有效性.
主要方法:
- 露出Ruditapes philippinarum不同度的纳米塑料.
- 使用了体外细胞检测 (增殖,细胞毒性) 和先进的建模技术.
- 评估了生物体的反应,包括生长,氧化应激,脂质过氧化和DNA损伤.
主要成果:
- 纳米塑料在双动物中诱导了显著的不良影响:生长抑制 (69.5-108%),氧化应激,脂质过氧化和DNA损伤.
- 实验室细胞增殖试验和预测模型显示,与体内生长抑制结果 (54.7-104%) 强烈一致.
- 在体外细胞毒性和生物体的毒理反应之间确立了明确的相关性.
结论:
- 将计算建模与体外毒性测试相结合,为预测纳米塑料对双动物的影响提供了一种可靠的方法.
- 这种方法为海洋盆地生态系统中纳米塑料的环境风险评估提供了宝贵的见解.
更多相关视频
相关概念视频
01:28Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
01:23Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...