索塔格利弗洛辛在SOLOIST-WHF中的成本效益
William S Weintraub1, Paul Kolm2, Sarahfaye Dolman2
1MedStar Health Research Institute, Washington, DC, USA; Department of Medicine, Georgetown University, Washington, DC, USA.
JACC. Heart failure
|June 15, 2024
概括
索塔格利弗洛辛对于糖尿病和心力衰竭患者来说是具有成本效益的,提供了改善质量调整的寿命年. 这一分析为心力衰竭管理中的治疗决策提供了宝贵的经济见解.
科学领域:
- 药物经济学 药物经济学
- 心血管医学 心血管医学
- 糖尿病管理 糖尿病管理
背景情况:
- SOLOIST-WHF试验表明,索塔格利弗洛辛在糖尿病患者中有效,最近的心力衰竭恶化.
- 在这个人群中,索塔格利弗洛辛的成本效益仍然没有得到研究.
研究的目的:
- 为了确定sotagliflozin在糖尿病患者和最近心力衰竭恶化的患者的成本效益.
- 在美国医疗保健背景下评估sotagliflozin的经济价值.
主要方法:
- 使用来自SOLOIST-WHF试验 (N=1,222) 的数据开发了一个马尔科夫模型.
- 从美国医疗保健部门的角度估计了终身成本和经质量调整的寿命年 (QALY).
- 成本数据来源于国家住院患者样本,实用性评估来自已发表的报告.
主要成果:
- 与安慰剂相比,索塔格利弗洛辛的寿命QALY (4.43对4.04) 和成本 (220113美元对188198美元) 更高.
- 每个获得的QALY的增量成本效益比为81,823美元.
- 在分别为10万美元和15万美元的支付意愿门时,成本效益概率达到67.5%和89.4%.
结论:
- 索塔格利弗洛辛在美国被认为是糖尿病患者和最近心力衰竭恶化的成本有效药物.
- 这些发现支持sotagliflozin在心力衰竭治疗的普遍接受的支付意愿门内使用.
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