关于在使用持久,连续流动心室辅助器件的患者中预防和管理血红相容性相关不良事件的策略的ISHLT共识声明
Ian B Hollis1, Douglas L Jennings2, Selim Krim3
1University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina; University of North Carolina Medical Center, Chapel Hill, North Carolina.
概括
持续流动左心室辅助装置 (CF-LVAD) 患者面临着与血红相容性相关的不良事件 (HRAE) 的持续风险. 这份共识声明为预防和管理这些关键并发症提供了基于证据的指导.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 血液学 血液学 血液学
背景情况:
- 增加持续流动左心室辅助器件 (CF-LVADs) 患者的预期寿命.
- 与血液相容性相关的不良事件 (HRAE) 仍然是CF-LVAD患者发病率和死亡率的重要原因.
- 需要更新基于证据的CF-LVAD护理实践.
研究的目的:
- 提供关于CF-LVAD患者HRAE预防和管理的当前文献的全面评估.
- 引导临床医生优化抗血栓治疗和设备管理.
- 在CF-LVAD接受者中减少与HRAE相关的发病率和死亡率.
主要方法:
- 对CF-LVADs中HRAE的现有文献进行系统审查和综合.
- 由专家开发的基于共识的建议.
- 对抗血栓策略的评估 (口服和肠道抗凝剂,抗血小板).
主要成果:
- 口服抗凝血剂和抗血小板药物的最佳管理至关重要.
- 详细介绍了管理高风险HRAE患者的策略.
- 提供了关于管理血栓/出血事件和设备管理的指导.
结论:
- 有效预防和管理HRAE对于改善CF-LVAD患者的治疗结果至关重要.
- 这份共识声明为临床医生提供了关键指导.
- 优化护理可以减轻风险,改善CF-LVADs患者的生存率.
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