基本微量元素和酸胆重塑:对身体组成和胰岛素耐药性的影响
Wen-Ling Lin1, Mu-Ming Chien2, Sangopas Patchara1
1School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan, ROC.
概括
重要微量元素可能会破坏脂质代谢,增加胰岛素耐药性风险. 过度暴露于,铜和等元素与不健康的体重和改变的酸丁胆 (PC) 和酸丁胆 (LysoPC) 途径有关.
科学领域:
- 代谢学 代谢学 代谢学
- 微量元素分析 微量元素分析
- 人体生理学 人体生理学
背景情况:
- 生物活性脂类酸丁胆 (PCs) 和酸丁胆 (LysoPCs) 与代谢健康有关,但研究结果不一致.
- 微量元素对PC-LysoPC重塑和胰岛素抵抗 (IR) 风险的影响还不清楚.
研究的目的:
- 调查基本微量元素与PC-LysoPC代谢之间的关系.
- 确定微量元素是否影响胰岛素抵抗 (IR) 的风险.
主要方法:
- 收集了99名成年人的人体测量和生化数据.
- 使用ICP-MS测量了基本微量元素,使用UPLC-MS测量了脂质代谢物 (PC,LysoPC).
- 分析了微量元素,脂质代谢物和像Lp-PLA2.2.这样的IR标记物之间的相关性.
主要成果:
- 基本金属 (Se,Cu,Ni) 与PC呈反相关,与LysoPC呈正相关 (O-18:0/0:0).
- 增加的必需金属与较高的血清Lp-PLA2水平相关.
- 含有低必需金属的高PC与较低的IR风险相关 (OR=0.24),而高LysoPC(O-18:0/0:0) 和高必需金属则显著增加了IR风险 (OR=8.22).
结论:
- 过度暴露于必需的/可能必需的微量元素可能会促进不健康的体重和胰岛素抵抗.
- 微量元素对PC-LysoPC重塑通路的调制是IR发展的一个潜在机制.
- 维持基本微量元素的平衡对于代谢健康至关重要.
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