在犬卵巢瘤中CD117表达
Hannah E Mallon1, Gustavo A Ramírez2, Tamara Dolenšek3
1Department of Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
Journal of comparative pathology
|June 15, 2024
概括
狗卵巢瘤经常表达氨酸激酶受体CD117,这是一个潜在的生物标志物. 正常的卵巢组织不会表达CD117,这表明它在犬类卵巢癌中的作用.
科学领域:
- 兽医病理学 兽医病理学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 狗卵巢癌带来了诊断和治疗方面的挑战.
- 瘤异质性使组织学识别复杂化.
- 目前的治疗方法仅限于外科切除.
研究的目的:
- 在犬卵巢瘤中研究氨酸激酶受体CD117的新表达.
- 为了确定CD117是否可以作为诊断或预后生物标志物.
- 探索CD117作为犬卵巢癌的潜在治疗标.
主要方法:
- 免疫组织化学用于检测29只犬卵巢瘤样本中的CD117表达.
- 半定量评分评估了CD117标记强度和位置 (膜体,细胞质).
- 评估了基因组学形态,细胞素7,线粒体指数,亡和血管入侵.
主要成果:
- 81%的犬卵巢瘤表现出CD117新表达,而正常的卵巢组织没有.
- 在卵巢癌和粒状细胞瘤中检测到CD117.
- 在CD117表达和临床病理因素之间没有发现显著的关联.
结论:
- 在大多数犬卵巢瘤中,CD117是新表达的,这将它们与正常组织区分开来.
- CD117代表了一种对犬卵巢瘤有前途的生物标志物.
- 需要进一步的研究来确定CD117.的预后和治疗影响.
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