未充分利用的药用植物和复合面粉的表征,植物化学概况,抗氧化剂和细胞毒性
Neha Singh1, Nipanshi Tyagi2, Manish Singh3
1Department of Food Technology, Bhaskaracharya College of Applied Science, University of Delhi, New Delhi, India.
Food chemistry
|June 15, 2024
概括
分析了药用植物粉和复合面粉的特性. 优化的复合面粉甲醇提取物显示出高的抗氧化剂和细胞活力,具有对癌症蛋白质有希望的in silico结果.
科学领域:
- 药理学是指药理学,它是指药理学.
- 材料科学 材料科学 材料科学
- 计算化学计算化学
背景情况:
- 药用植物是生物活性化合物的丰富来源.
- 植物衍生材料的表征对于其应用至关重要.
- 了解植物化学相互作用与生物点是药物发现的关键.
研究的目的:
- 分析三种药用植物粉和一个复合面粉的物理化学特性.
- 评估植物提取物的抗氧化,细胞毒性和自由基清除活动.
- 通过in silico研究,调查已识别的植物成分的潜在治疗应用.
主要方法:
- 场发射扫描电子显微镜与能量分散式X射线光谱学 (FESEM/EDS)
- 在X射线衍射 (XRD) 中.
- 气相色谱-质谱 (GCMS) 是一种气相色谱技术.
- 里埃转换红外光谱法 (FTIR) 是一种红外光谱法.
- 在体外抗氧化剂和细胞活力测定.
- 在形分子对接研究中,分子对接研究.
主要成果:
- FESEM/EDS揭示了各种粒子形状,其中Withania显示了圆到圆的粒子.
- 大多数粉末的XRD表示半晶体性质,除了无形草.
- 甲醇和乙醇提取物显示出显著的抗氧化剂和总含量.
- 优化复合面粉 (OCF) 甲醇提取物表现出最高的总含量,强大的细胞活力对抗A549细胞,以及强大的自由基清除活性.
- GCMS和FTIR证实了必需植物成分和功能组的存在.
- 在体研究表明,乙烯基异甲酸,3-脱氧-d-曼诺酸乳和4,5-胺-2-氧胺对BAX,P53和EGFR蛋白质具有良好的结合亲和力和低毒性.
结论:
- 描述的药用植物粉末和OCF具有宝贵的植物化学特征.
- OCF甲醇提取物显示出显著的抗氧化剂和潜在的抗癌性质.
- 已识别的植物成分显示出有前途的治疗剂,具有有利的形状.
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