瘤微环境中的巨细胞两极分化:新兴的作用和治疗潜力
Wenru Zhang1, Mengmeng Wang1, Chonghao Ji2
1Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
概括
瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的关键免疫细胞. 了解TAM两极化对于开发针对瘤进展的有效癌症免疫疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 瘤微环境 (TME) 包括瘤细胞和宿主层,包括免疫细胞,内皮细胞和纤维细胞.
- 瘤相关巨细胞 (TAMs) 是TME内的主要免疫细胞.
- TAM存在于两极化状态,主要是M1 (抗瘤) 和M2 (前瘤) 亚型,影响癌症的进展.
研究的目的:
- 审查目前对控制TME内的巨细胞两极分化因素的研究.
- 检查巨细胞两极分化对瘤发育和进展的影响.
- 探索治疗策略,以调节癌症免疫疗法中的TAM两极化.
主要方法:
- 对最近的调查进行文献评论.
- 在TME中影响巨细胞极化因素的分析.
- 综合了有关TAM极化在瘤生物学中的作用的数据.
主要成果:
- 巨细胞两极分化是由TME内的各种因素调节的.
- 在TAM两极分化显著影响瘤的启动,生长和转移.
- TAMs的特定极化状态与不同的临床结果相关.
结论:
- TAMs是TME和癌症进展的关键调节者.
- 向巨细胞两极分化为新型癌症疗法提供了一个有希望的途径.
- 调节TAM极化有可能提高癌症免疫治疗的疗效.
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