皮克林乳液配送系统:对刺激有反应的生物矿物化颗粒作为颗粒乳化剂和生物活性载体
Haoyue Hou1, Yuli Zhang1, Yu Liu1
1School of Life Science and Engineering, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Colloids and surfaces. B, Biointerfaces
|June 15, 2024
概括
这项研究介绍了一种新的刺激响应皮克林乳液系统,用于共同输送脆弱的生物活性化合物. 该系统增强了素和黄素的稳定性和活性,使其能够按需释放,从而获得全面的健康益处.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 药物运输 药物运输 药物运输
背景情况:
- 皮克林乳液具有生物活性递送的潜力,但在保护脆弱化合物和控制释放方面存在困难.
- 由于稳定性和释放限制,多种生物活性物质的联合交付仍然具有挑战性.
研究的目的:
- 利用生物矿物化颗粒稳定皮克林乳液开发一种对脆弱生物活性物具有刺激反应的共同交付系统.
- 为了增强联合递送的水友性 (素) 和水害性 (素) 生物活性物质的稳定性和活性.
- 为了实现由特定刺激触发的生物活性物质的按需释放.
主要方法:
- 生物矿物化被用来在碳酸颗粒 (PPS@CaCO3) 中封装和固定水友性素.
- 这些生物矿物化颗粒作为油在水 (O/W) 皮克林乳液的稳定剂,在分散阶段封装了疏水性黄素.
- 试验室研究评估了同时输送的生物活性剂的稳定性,活性增强和酸诱导释放.
主要成果:
- 在皮克林乳液系统中成功地联合封装了素和黄素.
- 与它们的自由状态相比,素 (7.33倍) 和黄素 (144.83倍) 的活性显著增强.
- 通过生物矿物化颗粒的酸诱导水解,证明了两种生物活性物具有高活性保留的刺激反应共释放.
结论:
- 开发的响应刺激的皮克林乳液系统有效地共同提供脆弱的生物活性物质,增强稳定性和活性.
- 生物矿化和皮克林乳液稳定为封装的生物活性物提供了强大的保护.
- 这个平台提供了一个有前途的战略,用于控制多种生物活性化合物的联合交付,用于全面的健康应用.
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