禁食重塑组织特定的,以提高NK细胞介导的抗瘤免疫力
Rebecca B Delconte1, Mark Owyong2, Endi K Santosa2
1Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Immunity
|June 15, 2024
概括
禁食增强了自然杀手 (NK) 细胞的抗瘤免疫力,通过促进它们重新分发到骨髓和代谢重新连接. 这种饮食限制策略显示了改善癌症免疫治疗结果的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢调节 代谢调节 代谢调节
- 癌症生物学 癌症生物学
背景情况:
- 禁食与改善癌症结局有关.
- 禁食在自然杀手 (NK) 细胞抗瘤免疫力中的作用需要进一步研究.
研究的目的:
- 研究周期性禁食对NK细胞抗瘤免疫力的影响.
- 阐明禁食期间NK细胞反应背后的机制.
主要方法:
- 在小鼠模型中研究了NK细胞依赖的抗瘤免疫力.
- 分析了NK细胞的再分布,代谢的重新连接 (CPT1A表达) 和贩运媒介 (S1PR5,CXCR4).
- 通过骨髓 (BM) 髓状细胞和IFN-γ生产评估了原始化.
主要成果:
- 循环禁食通过NK细胞改善了对固体和转移性瘤的免疫力.
- 禁食诱导NK细胞重新分配到BM,并减少了人类的循环NK细胞.
- 禁食小鼠的NK细胞显示脂肪酸代谢 (CPT1A) 增强,并由IL-12+ BM髓质细胞进行原始化.
结论:
- 饮食限制,特别是禁食,优化先天免疫反应,特别是NK细胞功能.
- 禁食诱导的代谢和贩运适应增强NK细胞的抗瘤活性.
- 这些发现表明,禁食是增强癌症免疫疗法的潜在辅助策略.
更多相关视频
相关概念视频
Cytotoxic T Cells-mediated Immune Response
889
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
889
Cells of the Innate Immune Response
1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K
Cell-mediated Immune Responses
68.1K
Overview
68.1K
Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
Tumor Immunotherapy
511
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
511


