在接受重大妇科瘤手术的患者中术后认知衰退:试点前性研究
Mallika Makkar1, Rebekah Hunter2, Anjali Kulkarni3
1Cumming School of Medicine, University of Calgary, Calgary, AB.
概括
在妇科瘤手术后,对老年人进行了术后认知衰退 (POCD) 的评估. 虽然迷你精神状态检查显示了最小的下降,但患者采访显示了主观的"脑雾"和注意力问题.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 神经科学是一个神经科学.
背景情况:
- 手术后的认知衰退 (POCD) 影响了手术后的注意力,记忆力和执行功能.
- 在非心脏手术后,POCD的发病率为10-25%,但对妇科瘤患者的数据有限.
研究的目的:
- 确定在55岁及以上接受重大妇科瘤手术的患者中POCD的发病率.
- 探索患者对手术后认知变化的主观体验.
主要方法:
- 一项前性,观察性,混合方法研究跟踪了24名接受妇科癌症手术的患者 (≥55岁).
- 迷你精神状态检查 (MMSE) 和半结构面试是在手术前和1个月和3个月后进行的.
- POCD被定义为从基线下降≥2点的MMSE得分.
主要成果:
- 两名患者在1个月后出现了1点的MMSE下降,在3个月后恢复;一名患者在3个月后出现了1点的下降.
- 定性访谈确定了1个月"脑雾"和3个月持续的轻度注意力/词汇寻找缺陷的主题.
- 该研究捕获了微妙的主观发现,这些发现并不总是反映在MMSE得分中.
结论:
- 定性数据表明,在妇科瘤患者中,即使MMSE得分变化很小,也可能存在POCD.
- 需要进行更大规模的研究来证实这些发现.
- 可能需要更全面的神经心理测试来检测微妙的认知缺陷.
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