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Updated: Jun 23, 2025

Mapping Mammalian 3D Genome Interactions with Micro-C-XL
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NucMap 2.0:全基因组核细胞定位图的最新数据库,跨物种的位置地图

Zhi Nie1, Yongbing Zhao2, Shuhuan Yu1

  • 1National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Journal of molecular biology
|June 15, 2024
PubMed
概括

NucMap 2.0扩展了全基因组的核细胞定位地图,跨越更多物种,并集成了多omics数据. 该资源有助于研究人员了解基因调节和DNA过程.

关键词:
染色质可访问性 染色质可访问性基因调节 基因调节 基因调节基斯顿基因基因基因基因基因基因基因基因基因基因基因基因基因基因多种主题的多种主题.转录因子的转录因子

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
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DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
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Euchromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
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