对于复发的卵膜黑色素瘤进行质子疗法后的视觉结果
Megan S Steinkerchner1, Caleb D Hartley1, Anne M Lane1
1Ocular Melanoma Center, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Ophthalmology. Retina
|June 15, 2024
概括
质子束再辐射 (PBI) 为复发性阴道黑色素瘤提供了全球保护的选择,在一些患者中保持了功能视力. 然而,在PBI救援疗法后,视力敏度结果可能是可变的.
科学领域:
- 眼科医生 眼科 眼科
- 辐射瘤学 辐射瘤学
- 在瘤学瘤学.
背景情况:
- 卵巢黑色素瘤复发需要救援治疗.
- 质子束再辐射 (PBI) 是保护地球的替代方案,用于局部复发.
- 评估PBI后的视觉结果对于治疗规划至关重要.
研究的目的:
- 为了评估复发性阴膜黑色素瘤的质子束救援疗法后的视力敏度 (VA) 结果.
- 为了确定影响VA后PBI的预后因素.
- 为了确定复发性阴膜黑色素瘤的PBI后的化率.
主要方法:
- 用PBI治疗的复发性阴膜黑色素瘤患者的回顾性研究.
- 收集的数据包括患者和瘤特征,最佳视力敏度 (BVA) 和眼部结果.
- 多变量考克斯模型用于分析VA的预后因素.
主要成果:
- 67名患有复发性阴道黑色素瘤的患者接受了PBI.
- 最终BVA的中位数是手动;9.1%的人保持VA 20/40或更好.
- 较差的初始VA (20/40) 预测PBI后的较差结果 (20/200或更差). 18%的人经历了核切除.
结论:
- 质子束辐射可以保存地球球,并为某些患有复发性阴膜黑色素瘤的患者提供功能性视力.
- 挽救PBI是一个可行的选择,但视觉结果是可变的.
- 患者的选择和治疗前的视力敏度是重要的预后因素.
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