2001年至2020年在台湾的辅助生殖技术,多胎生育和围产期结果
Tsung Yu1, Li-Hsien Chiu1, Ta-Sheng Chen2
1Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
The Journal of pediatrics
|June 15, 2024
概括
台湾的辅助生殖法在辅助生殖技术 (ART) 的分娩中减少了多胎,早产,低出生体重 (LBW) 和小于妊娠年龄 (SGA). 该法律导致这些不良周产期结果的显著减少.
科学领域:
- 生殖医学 生殖医学
- 公共卫生政策 公共卫生政策
- 围产期流行病学 围产期流行病学
背景情况:
- 辅助生殖技术 (ART) 与多胎儿和不良周产期结果的风险增加有关.
- 台湾在2007年实施了辅助生殖法,以限制胚胎移植,旨在减轻这些风险.
研究的目的:
- 评估台湾的辅助生殖法对多胎,早产,低出生体重 (LBW) 和小于妊娠年龄 (SGA) 在ART分娩中的趋势的影响.
- 分析法律实施前后这些结果的时间变化.
主要方法:
- 分析了2001-2020年活产数据,包括超过71,000例ART分娩.
- 对ART和非ART分娩的倍数和产周期结果的年率的计算.
- 使用中断时间序列分析来评估法案对结果趋势的影响.
主要成果:
- 在干预后,ART分娩的倍数 (-10.63 /年),早产 (-6.74 /年),LBW (-9.38 /年) 和SGA (-4.48 /年) 的比例呈现出显著下降趋势.
- 在该法案实施后,SGA利率 (-53.45) 立即显著下降.
- 对于所有研究结果,人口归因风险在干预前后都增加了.
结论:
- 自2008年以来,台湾的辅助生殖法已经有效地减少了ART分娩中的不良周产期结果,包括多胎,早产,LBW和SGA.
- 该立法对降低SGA税率产生了显著的直接影响.
更多相关视频
09:51Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
Published on: March 21, 2018
19.6K
07:02Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
Published on: May 16, 2019
12.7K
相关概念视频
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Reproductive Cloning
30.3K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
30.3K
CRISPR
50.5K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
50.5K
Cloning of Dolly the Sheep
3.5K
The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual, the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
3.5K
In Vitro Fertilization
239
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
239
