在中国年轻成年人中,特定的饮食模式,肠道微生物组合和发生的下值抑郁症之间的关联
Xiumin Jiang1, Xiaotong Wang2, Meng Zhang3
1Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China; South China Research Center for Acupuncture and Moxibustion, Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Journal of advanced research
|June 15, 2024
概括
特定的饮食模式和肠道微生物群组成与年轻成年人的下值抑郁症 (SD) 有关. 富含豆类,谷物,坚果和水果的健康饮食可以通过影响肠道细菌来降低SD风险.
科学领域:
- 营养精神病学 营养精神病学
- 微生物组研究 微生物组研究
- 心理健康研究 心理健康研究
背景情况:
- 在年轻成年人中,低于值的抑郁症 (SD) 了解得很少,对促成因素的知识有限.
- 研究饮食,肠道微生物群和SD之间的关系对于理解心理健康发展至关重要.
研究的目的:
- 检查SD的年轻成年人的饮食习惯和肠道微生物群组成.
- 探索这些因素与SD的发生之间的关联.
主要方法:
- 对178名患有SD的年轻成年人和114名健康对照 (18-32岁) 的横截面研究.
- 使用多个经过验证的尺度 (SDS,SAS,BDI-II,HAMD-17,PSQI) 评估SD.
- 便微生物特征的元基因组测序和饮食模式的因素分析 (FFQ).
主要成果:
- 饮食模式I和IV与SD风险降低有关 (ORs<0.4).
- 患有SD的年轻人表现出明显的肠道微生物特征,多样性增加和分类学变化.
- Veillonella atypica被确定为一个潜在的调解者,将抑郁症得分与健康的饮食模式联系起来.
结论:
- 在年轻人中,饮食模式,肠道微生物群和SD风险之间存在复杂的相互作用.
- 饮食干预和微生物组调制显示出在这个人口群体中促进心理健康的潜力.
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