用免疫疗法治疗软组织肉瘤的趋势
Yoshiko Iwai1, Xavier L Baldwin1, Timothy Feeney2
1Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
American journal of surgery
|June 15, 2024
概括
在软组织肉瘤 (STS) 中,免疫瘤学 (IO) 治疗的使用率较低,但在增长中,主要用于转移性病例. 需要进一步的研究,以找到生物标志物并改善这种癌症的治疗机会.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 免疫瘤学 (IO) 治疗在软组织肉瘤 (STS) 中的应用仍然在很大程度上未经检查.
- 这项研究旨在描述STS患者群体内IO治疗的利用模式.
研究的目的:
- 分析软组织肉瘤患者接受免疫瘤治疗的趋势和因素.
- 了解当前的IO疗法在STS中的使用情况.
主要方法:
- 国家癌症数据库 (2011-2021) 对软组织质量患者的回顾性分析.
- 根据IO治疗接收状态对患者的分类.
- 统计分析包括千平方测试,比例趋势测试和多变量后勤回归,以确定影响IO接收的因素.
主要成果:
- 在103,092名STS患者中,1.9%接受或推接受IO治疗.
- IO治疗的使用量从2011年的0.24%增加了十倍,到2021年的2.5% (p < 0.0001).
- 在患有高度瘤,转移性疾病以及在学术研究中心接受治疗的患者中观察到IO接收的几率更高 (p < 0.001).
结论:
- 在软组织肉瘤中,免疫瘤治疗的使用率目前很低,但显示出日益增长的趋势.
- IO治疗主要用于转移性STS的转移性环境.
- 未来的研究应该集中在识别可预测IO反应的生物标志物和理解STS治疗准入的促进者.
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