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相关概念视频

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

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Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation02:47

Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation

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Introduction
One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
18.0K
Protection of Alcohols02:31

Protection of Alcohols

7.3K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
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Introduction to Functional Groups02:08

Introduction to Functional Groups

26.0K

Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.  
Types of common functional groups
The table below summarizes some of the major functional...
26.0K
Reduction of Alkenes: Catalytic Hydrogenation02:13

Reduction of Alkenes: Catalytic Hydrogenation

12.0K
Alkenes undergo reduction by the addition of molecular hydrogen to give alkanes. Because the process generally occurs in the presence of a transition-metal catalyst, the reaction is called catalytic hydrogenation.
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the...
12.0K
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation02:24

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

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Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
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Updated: Jun 23, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

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功能组可以容忍借用C-基化的功能组.

Elliot P Bailey1, Timothy J Donohoe2, Martin D Smith3

  • 1Chemistry Research Laboratory, University of Oxford, Oxford, UK.

Nature communications
|June 15, 2024
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的,更温和的借用方法,一种可持续的碳-碳键形成技术. 它允许在室温下更大的功能组耐受性,扩大其在有机合成中的实用性.

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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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科学领域:

  • 有机化学 有机化学
  • 可持续化学 可持续化学
  • 催化剂是一种催化剂.

背景情况:

  • 借用使酒精能够在C-C键形成中取代基化物.
  • 目前的方法往往需要恶劣的条件 (高温,坚固的基础),限制功能组的耐受性.

研究的目的:

  • 为了开发一个室温,功能组宽容的借用方法.
  • 扩大可用于借用反应的酒精的范围.

主要方法:

  • 在温和的,亚微基质的基本条件下使用简单的催化剂.
  • 采用无氧条件来稳定化中间体.
  • 在室温和中度升高温度下研究反应性.

主要成果:

  • 实现了室温用借用,具有高功能组容忍度.
  • 证明了与以前不相容的酒精的成功反应.
  • 扩大基质范围,以使用略高的温度使用富含的异循环.

结论:

  • 开发了一种更温和,更通用的借款协议.
  • 无氧条件对于催化剂的稳定性和高产量至关重要.
  • 该方法扩大了基于酒精的可持续化方法的应用范围.