为生物医学应用而制造和表征独特的持续改性奇托桑纳米颗粒
Marwa ElS Ahmed1, Mansoura I Mohamed2, Hanaa Y Ahmed3
1Chemistry Department, Faculty of Women for Art, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt.
Scientific reports
|June 15, 2024
概括
素衍生物是使用甲和交叉连接剂合成的. 由此产生的素纳米粒子 (CS-3NPs) 对HeLa细胞表现出显著的抗癌活性,显示出作为抗瘤剂的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 癌症研究 癌症研究
背景情况:
- 酸盐 (CS) 是一种多功能生物聚合物,具有有利的生物医学特性,包括生物相容性和抗菌活性.
- 甲 (1) 是一种天然存在的化合物,在制药,食品和化品中具有多种应用.
- 开发具有增强治疗性能的新型素衍生物对于推进生物医学应用至关重要.
研究的目的:
- 合成具有改善物理化学和抗癌性质的新型基托衍生物.
- 为了评估这些衍生物对人类癌症细胞系的细胞毒性.
- 探索基托桑纳米颗粒作为抗瘤剂的潜力.
主要方法:
- 希夫基形成在奇托和注射甲基之间,以创建 (CS-1) 衍生物.
- 使用聚乙烯糖醇二甲乙烯 (PEGDGE) 形成 (CS-2) 和三聚酸 (TPP) 形成 (CS-3NPs) 的奇托衍生物的交叉连接.
- 化学结构和物理化学性质的表征 (结晶性,热稳定性).
- 在实验室对HeLa和HEp-2癌细胞系的细胞毒性评估.
主要成果:
- 合成的基托衍生物 (CS-2和CS-3NPs) 已成功地被表征.
- (CS-3NPs) 表现出增强的结晶性,而 (CS-2) 与原生奇多相比显示出优越的热稳定性.
- (CS-3NPs) 对HeLa细胞表现出显著的细胞毒性,增长抑制90.38%,亡30.3%,IC50为108.01μg/ml.
结论:
- 素纳米粒子 (CS-3NPs) 对HeLa细胞具有强大的抗癌活性.
- 开发的奇托衍生物作为癌症治疗的治疗剂具有前途.
- 对于抗瘤应用的基托基纳米颗粒的进一步研究是有必要的.
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