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芝麻醇通过激活老年肥胖小鼠的AKT/mTOR/FoxO1信号通路来缓解肉
Jinxin Yang1, Zhipeng Wang1, Yan Xie1
1Xiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Plant foods for human nutrition (Dordrecht, Netherlands)
|June 15, 2024
概括
芝麻是一种芝麻种子化合物,通过促进蛋白质合成和通过AKT/mTOR/FoxO1通路抑制降解来对抗与年龄和肥胖相关的肌肉损失 (肉症).
科学领域:
- 生物化学 生物化学
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
背景情况:
- 芝麻醇是一种来自芝麻种子的生物活性化合物,具有药用特性.
- 芝麻醇对与衰老和肥胖相关的肉症的影响尚不清楚.
- 萨科佩尼亚是老龄化和肥胖人口的重大健康问题.
研究的目的:
- 研究芝麻醇对老年和肥胖小鼠的萨尔科佩尼亚的保护作用.
- 阐明芝麻醇对肌肉健康作用的潜在分子机制.
- 评估芝麻醇在代谢性肌肉并发症中的潜在治疗作用.
主要方法:
- 使用老年和肥胖的C57BL/6J雄性小鼠模型,食高脂肪饮食.
- 使用C2C12菌根管与D-银糖和棕酸联合处理,用于体外分析.
- 分析了AKT/mTOR/FoxO1信号通路和关键蛋白调节者的激活.
主要成果:
- 芝麻醇的使用上调了p-p70S6K和p-4EBP1,增强了肌肉蛋白质的合成.
- 芝麻醇降低了Atrogin-1和MuRF1的调节,抑制了肌肉蛋白质的降解.
- 在体内和体外的研究证实了芝麻醇通过AKT/mTOR/FoxO1通路改善了肉症.
结论:
- 芝麻醇有效地减轻与衰老和肥胖相关的缩症.
- 该机制涉及到AKT/mTOR/FoxO1信号通路的激活.
- 芝麻醇在衰老和肥胖中的代谢性肌肉并发症中显示出治疗潜力.
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