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是因果关系还是混关系? 应用E值来检查超加工食品消费与体重增加风险之间的关联
1Institute of Population Health, University of Liverpool, Liverpool, UK. eric.robinson@liv.ac.uk.
International journal of obesity (2005)
|June 15, 2024
概括
超加工食品 (UPF) 的消费可能不会直接导致体重增加. 未测量的因素可以解释UPF和成人体重增加之间的观察到的联系.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 肥胖问题研究研究
背景情况:
- 观察性研究表明,超加工食品 (UPF) 消费与体重增加之间存在联系.
- 从观测数据的因果推断受到潜在的未测量混的挑战.
- 在UPF与体重增加的关联中,未测量的混的作用需要进一步调查.
研究的目的:
- 引入E值作为评估肥胖研究中未测量的混的工具.
- 量化未测量的混因子对UPF-体重增加关联的潜在影响.
- 评估混解释观察到的关联的可信性.
主要方法:
- 对UPF消费和成人体重增加的前性研究的元分析.
- 应用E值方法对元分析效果估计的应用.
- 假设混场景的插图.
主要成果:
- 分析显示,较高的UPF消费与体重增加相关 (RR=1.14).
- 计算出的E值为1.55.
- 这表明,未测量的混因子与小到中等的关联可以解释观察到的UPF-体重增加的联系.
结论:
- 不测量的混可能解释了UPF消费和体重增加之间的潜在关联.
- 需要高质量的观察性研究来控制混因素.
- 建议从研究设计中获得证据,以尽量减少混.
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